[1] These incretin-based therapies have gained significant attention due to their effectiveness in lowering blood glucose levels and promoting weight loss
Establish baseline measurements
Do not use solution that has been reconstituted for more than 28 days, even if it appears clear
Side effects are managed by going up slowly on the dose or reducing the dose if it starts to cause nausea
Different GLP-1 medications reach steady-state concentrations at different ratesliraglutide within approximately 3 days, dulaglutide within 2-4 weeks, and semaglutide within 4-5 weeks, according to their respective MHRA-approved prescribing information
Loomba R et al., SYNERGY-NASH, NEJM 2024 (NEJMoa2401943, PMID 38856224) : tirzepatide and MASH, resolution in 62% at the 15 mg level