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J Clin Invest 1967;46:195462

Similarly, those scheduled for major surgery should discuss timing of GLP-1 injections or oral doses with their surgical team, as any medication affecting blood vessel function deserves consideration in perioperative planning

A qualified provider should monitor both treatments in parallel, adjusting doses independently as needed

Prior history of ulcer or other gastrointestinal complications increase risk of NSAID ulcers 4- to 5-fold

Retrieved 3 January 2025

However, the underlying mechanism by which MTX provokes tissue injury is not yet well known, and direct toxic effects of MTX are thought to be caused by excessive generation of free radicals, causing an imbalance between free radical production and antioxidant defense, which finally results in the development of oxidative stress (Drishya et al