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Post- L-GSH supplementation, we found increased levels of IFN- in PBMCs ( Figure 5A ), increased levels of TNF- in plasma ( Figure 5C ) and PBMCs ( Figure 5D ), and increased levels of IL-2 in plasma ( Figure 5E ) and PBMCs ( Figure 5F ) when compared to before L-GSH supplementation

However, determining how long to remain on these medications requires careful consideration of several factors

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First, melatonin appears most useful where oxidative load is high (e.g., PCOS, diminished ovarian reserve, repeat-poor response), aiming to improve oocyte/embryo competence rather than to replace first-line ovulation-induction strategies

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