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observations, are shown in Figure 3A

These findings provide valuable insights into the evolving landscape of obesity management in this population

GLP-1 drugs like semaglutide can raise uric acid levels through multiple pathways: rapid weight loss mobilizes stored purines from fat tissue, reduced fluid intake during nausea decreases uric acid dilution in urine, and the medications themselves may alter kidney handling of uric acid

The recurring interplay of oxidative stress, inflammatory activation, and disrupted cellular signalling provides a unifying mechanistic framework linking renal, musculoskeletal, cutaneous, immunological, respiratory, gastrointestinal, and reproductive dysfunctions to those already described in cardiovascular, hepatic, and gonadal tissues (83)

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