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A modest but significant LBM loss (2%) also occurred
"Until more data on solid diets is available, a conservative approach with a liquid diet while continuing therapy is advisable." The findings were reported in the paper, Quantified Metrics of Gastric Emptying Delay by Glucagon-Like Peptide-1 Agonists: A Systematic Review and Meta-Analysis With Insights for Periprocedural Management, published in The American Journal of Gastroenterology
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It rose clearly above placebo (up to ~12.5% vs 0.9%) but rarely drove discontinuation
Additionally, in response to a meal, in patients with short bowel syndrome with a preserved colon (jejuno-colonic anastomosis), both baseline GLP-1 and GLP-2 are elevated with GLP-2 levels threefold greater than control patients (average concentration of 72 pmol/L), which persists throughout the post-prandial period (Jeppesen et al., 2000)
The relationship between rapid weight loss and mood is complex
