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It is separated from ingested food through the action of the gastric acid, and in the duodenum the vast majority binds to intrinsic factor (IF)

doi: 10.1002/ptr.6537, PMID: [DOI] [PubMed] [Google Scholar] 47.Hessen E, Lossius MI, Reinvang I, Gjerstad L

Much of the current evidence is preclinical (cell and animal studies), and human data is still limited

standard research-grade falls between 95% and 99%

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Many people find their optimal response at 5 mg, 7.5 mg, or 10 mg