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Crystal structures of the human CYP51A1VFV complex revealed a 2:1 inhibitor-to-enzyme binding ratio, explaining the enzymes broader substrate profile and reduced sensitivity to inhibition compared to fungal homologs [100]

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doi: 10.1038/mp.2009.116 41 KimHChenLLimGSungBWangSMcCabeMFet al

With regards to dystonia, cerebellar stimulation could help with some aspects of this disease [171], especially with posture, as recently shown in rodents by White and Sillitoe (2017 [63]

Because of this limitation, scientists have explored methods for extending peptide stability and duration