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We need 10% to 15% weight loss to affect cardiovascular disease, and greater than 15% to impact cardiovascular mortality and heart failure outcomes. Depending on the NuSH treatment, patients can achieve sustained weight loss of Bariatric surgery is a highly effective weight loss treatment that can lead to a 25% or greater reduction in body weight

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Dose reduction or slowing the escalation timeline allows gradual neurological adjustment without abandoning therapy entirely