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27,28 PARP members can be categorized into several groups, the poly-ADP-ribosyl transferases (e.g., PARP1, 2, and 5), the mono-ADP-ribosyl transferases (e.g., including PARP 3, 4, 68, and 1016) and RBPs (e.g., PARP7, 10, and 1214)