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Growth hormone and growth hormone secretagogue effects on nitrogen balance and urea synthesis in steroid-treated rats

J Clin Endocrinol Metab 89:51055109

169,170,171 Arginine from proteins can be catalyzed by PAD enzymes to citrulline, a process called citrullination, which is part of the normal immune process

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This paradigm shift operates through: (i) dual-function targeting (simultaneous antithrombotic action and regenerative promotion), (ii) spatiotemporal inflammatory reprogramming (controlled macrophage polarization), and (iii) synergistic regenerative factor delivery (orchestrated release of cardioprotective mediators) [62, 94](Fig