McIntosh AM, Job DE, Moorhead WJ, Harrison LK, Whalley HC, Johnstone EC et al (2006)
Choi MK, Jin S, Jeon JH, Kang WY, Seong SJ, Yoon YR, et al
The 24-hour delivery timeframe makes sense for maintaining steady metabolic support
Messers take aligns with that of the surgeons I interviewed: Higher rates of surgical wound reopening and delayed healing [in GLP-1 patients] may be linked to the drugs impact on gastrointestinal motility [the way food, liquid, and waste move through the stomach] and nutrient absorption, potentially leading to nutritional deficiencies that impair wound healing, says the endocrinologist
The basic formula Concentration (mg/mL) = Total peptide (mg) divided by Total water volume (mL) For a 10mg vial: 10mg divided by 1mL = 10mg/mL 10mg divided by 2mL = 5mg/mL 10mg divided by 3mL = 3.33mg/mL 10mg divided by 5mL = 2mg/mL Calculating your draw volume Draw volume (mL) = Desired dose (mg) divided by Concentration (mg/mL) Example: You want a 4mg dose from a vial reconstituted at 5mg/mL
Binding free energy calculation Among the various available approaches for binding free energy predictions, the molecular mechanics generalized Born surface area (MM/GBSA) method has been suggested to provide the rational results 54,55
