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[59] [60] Susan Elizabeth Blow, American educator and founder of the first publicly funded kindergarten in the United States, was forced to retire and seek treatment for Graves' disease in 1884

This is why continuous therapy, or planned tapering under medical supervision rather than abrupt discontinuation, tends to produce better long-term outcomes

151 Leptin-deficient mice (ob/ob) causes both obesity and diabetes due to hyperphagia and blunted metabolic rate, and treatment with exogenous leptin could prevent and reverse the obese phenotype

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Should retatrutide turn out to be safe and effective, it could potentially reshape the future of obesity treatment