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Supporting phase II detox of the 2-OH and 4-OH metabolites The 2-OH and 4-OH estrogen metabolites are cleared out in phase II primarily through methylation , which is carried out by the catechol-o-methyltransferase (COMT) enzyme

Beyond raw weight loss, the metabolic improvements were remarkable

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Altogether, these findings enhance our understanding of the molecular basis for acyl-ghrelin recognition and activation of the ghrelin receptor and provide a framework for the drug design targeting the ghrelin receptor

But, it doesnt necessarily mean that increased B12 levels cause weight loss

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