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Although the exact etiology is not well understood, oxidative stress is believed to play a significant role in their development

These therapies, which include well-known medications like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound), are helping millions of people worldwide achieve remarkable weight loss and better metabolic health

Rama Reddy NR, Mehta RH, Soni PH, Makasana J, Gajbhiye NA, Ponnuchamy M, Kumar J

These include homomeric GluK1 bound to agonist Glu (Selvakumar et al., 2021), homomeric GluK2 bound to the positive allosteric modulator (PAM) BPAM344 (BPAM) (Kumari et al., 2020)

Front Endocrinol 12:645617