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The increased risk for retinal complications (HR 1.76, P = 0.02) observed in subjects with retinopathy at baseline, probably due to the fast improvement of glucose control, suggests a careful use of semaglutide in these subjects [5]

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Li Y, Perry T, Kindy MS, Harvey BK, Tweedie D, Holloway HW et al (2009) GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

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"GLP-1s are a lifetime thing." The tennis star says despite facing some stigma around taking GLP-1s, shes also gotten plenty of positive reactions, and she plans to stay on some form of the medication for years to come