This isn't because 1:1 is mechanistically optimal in some provable way it's because researchers studying combinations of these compounds chose 1:1 as the default and the literature accumulated around that choice
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Some people believe that B12 can boost energy and help with weight loss in everyone, but this is based on a misunderstanding
Each lot of BPC-157 is independently tested
BPC-157 is a synthetic pentadecapeptide associated with gastric-derived cytoprotective systems and is studied for effects on fibroblast activity, endothelial signaling, angiogenesis-related pathways, and nitric oxide-linked signaling