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4.2 Regulation of ferroptosis by inflammatory cytokines and immune signaling 4.2.1 Classic proinflammatory cytokines IL-1 can induce the synthesis of matrix-degrading enzymes MMP-13 and ADAMTS-5 by chondrocytes and synovial cells (117)

The changes of ferroptosis and necroptosis levels were detected by CCK-8, western blot, quantitative real-time PCR, and electron microscopy

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Administer via intramuscular injection or intravenous (IV) injection