In obese, non-diabetic individuals, orforglipron administration for 36 weeks in a phase 2 trial, ranging from 12 mg to 45 mg doses, resulted in dose-dependent weight loss of up to 14.7%, accompanied by improvements in cardiometabolic risk factors [109] (Figure 6)
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[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Kusminski C.M., Bickel P.E., Scherer P.E