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201 Uric acid-lowering therapy effectively reduces both systolic and diastolic blood pressure in pediatric and adolescent patients newly diagnosed with essential hypertension, particularly in young individuals with a short duration of hypertension and preserved renal function

Dimensions: 5315 x 3541 px | 45 x 30 cm | 17.7 x 11.8 inches | 300dpi Date taken: 23 September 2014 Location: Canada Photographer: imageBROKER/Ignacio Yufera

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There are 2 primary mechanisms: Ascorbic Acid (Ascorbate) uptake using sodium-dependent vitamin C transporter (SVCT) 1 or 2 Ascorbic Acid (Ascorbate) Recycling Ascorbic Acid (Ascorbate) transport using sodium-dependent vitamin C transporter (SVCT) 1 or 2 As shown below, SVCT 1 and SVCT 2 transport ascorbic acid or ascorbate into the cell against the concentration gradient (represented by the orange wedge in the figure below)

doi: 10.1021/acs.jpcb.7b07002 107 KangM