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The reduction appears to be primarily due to decreases among individuals with the highest baseline scores

The glucagon receptor component increases energy expenditure and fat oxidation, while GLP-1 suppresses appetite and slows gastric emptying, and GIP enhances insulin secretion while potentially reducing nausea

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doi: 10.1016/S2468-1253(17)30285-6 176 SeufertJGallwitzB