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51 All residues were checked for fitting in electron density, and Ramachandran and rotamer restraints

This compound, known as exenatide, mimics the effects of GLP-1, a hormone that plays a critical role in appetite suppression, insulin secretion and glucose metabolism

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Neves JS, Vasques-Novoa F, Borges-Canha M, Leite AR, Sharma A, Carvalho D, Packer M, Zannad F, Leite-Moreira A, Ferreira JP

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174 Currently, Eli Lilly has initiated a Phase III development program to further investigate the efficacy and safety of orforglipron in treating obesity, overweight, and T2DM