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Two-way analysis of variance (ANOVA) or Multiple unpaired t tests were used for comparison between multiple groups, the Tukeys multiple comparisons or Holm-dk tests were used to correct the p -values for each group, respectively

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Another study showed that in JHU-083-treated cancer cell allograft models, an increase in nutrient levels and oxygen and a decrease in the acidity of the TME resulted in T-cell-mediated tumor suppression 145 , whereas another study demonstrated the effects of JHU-083 on myeloid-derived suppressor cells (MDSCs) and TAMs 150

The town council is striving to develop innovative regulatory approaches, particularly by creating new forms of social agreements that ensure the active participation of local communities in the ongoing transformations

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