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This is mechanistically demonstrated in breast cancer models, where SFN, by activating the Nrf2 pathway, reduces the secretion of prostaglandin E2 (PGE2) from tumor cells, thereby triggering MDSCs to switch from an immunosuppressive to an immunogenic phenotype and inhibiting their expansion (76)
Perrone at al
Both MDA and SOD levels were normalized per milligram of total protein
Advances in Gerontology, 1 , 328-339
Macrophage polarization
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