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Acknowledgments Figure 1 was created using BioRender

This means it is more likely to degrade at high temperatures and shows lower enzyme activity

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5AM-1MQ Selectively inhibits the Nicotinamide N-methyltransferase (NNMT) enzyme to increase cellular NAD+ levels and metabolic expenditure

This is clearly demonstrated in people living with DS, where the overexpression of CBS is a genetic consequence that causes a significant reduction of serum homocysteine concentration leading to less available methionine within the methionine cycle

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