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The TRIUMPH-4 result of 28.7% at 68 weeks exceeded the Phase 2 result, suggesting the effect strengthens with longer treatment

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Taken together, these biochemical results suggest that ultraviolet irradiation of the skin causes changes compatible with aging that manifest as a reduction in the content of pro-collagen type 1, elastin and sulfated GAGs, as well as an increase in MMP1 activity, and the CG treatment reverses these changes by increasing the levels of these extracellular matrix components, except for MMP1 activity, which can be attributed to its rejuvenating effect

Lalinde-Acevedo PC, Mayorga-Torres BJM, Agarwal A, et al