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[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Carrasco A., Recabarren M.P., Rojas-Garca P.P., Gutirrez M., Morales K., Sir-Petermann T., Recabarren S.E

Other considerations in weight management clinical trial reporting The use of the estimands concept in weight management trials opens up wider discussions about estimating and communicating treatment effects for weight management interventions

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These include: Nausea (affecting 20-40% of patients, though often transient) Vomiting and diarrhoea Constipation Abdominal pain and bloating Reduced appetite (which, whilst therapeutically desired, can occasionally be excessive) These effects typically diminish over several weeks as the body adjusts to the medication

The main sources of GLP-1 in the periphery are the enteroendocrine GLP-1 producing cells (GLP-1 EECs) found in the small intestine and colon