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Gastrointestinal Side Effects: Nausea (can be severe and can last several days to weeks) Vomiting (can be severe and lead to dehydration) Diarrhea Constipation Abdominal pain Hypoglycemia (Low Blood Sugar): While semaglutide itself is not known to cause hypoglycemia, it may occur when used in combination with other diabetes medications, especially insulin or sulfonylureas

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In the laboratory study Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo (Chen and colleagues, Proceedings of the National Academy of Sciences, 2007), pharmacologic ascorbate acted as a prodrug that formed hydrogen peroxide in the extracellular space but not in blooda route-dependent effect that oral dosing did not reproduce