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Pancreatitis awareness GLP-1 receptor agonists carry a theoretical risk of pancreatitis, though this has been rare in retatrutide trials specifically

Sample sizes were guided by prior experience with the db/db mouse model and were designed to provide 80% power ( = 0.05) to detect biologically meaningful differences in metabolic outcomes

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Those who are pregnant or breastfeeding , as the safety of these medications in pregnancy has not been established

This was compared to people taking a placebo, who lost an average of 3.1% of their starting body weight