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If you have established cardiovascular disease or high risk, the SELECT trial data suggests staying on semaglutide provides ongoing protection

Preferential tissue distribution to kidneys, liver, and gastrointestinal tract aligns with observed therapeutic effects in animal studies

Another assay developed showed that uric acid uptake applied to URAT1 overexpressing cells also indicated that 75 did not affect the transport activity of URAT1, the main target of current uricosuric drugs, revealing that 75 acted as a specific XO inhibitor with no direct effect on uric acid excretion

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