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Patients carrying the FTO rs9939609 A-allele variantassociated with higher baseline appetite driveoften respond more dramatically to tirzepatide's dual signaling

The Bottom Line Tirzepatide can be associated with temporary hair shedding, most commonly due to rapid weight loss and metabolic stress rather than permanent follicle damage

Given its peculiar tissue distribution, a role in the sperm maturation occurring in epididymal lumen has been proposed

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