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No large-scale clinical trials have been completed examining the blend's safety profile in humans

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It states: "HF [heart failure] is a complex clinical syndrome that results from any structural or functional impairment of ventricular filling or ejection of blood

2012 Feb-Mar;133(2-3):99-106.

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Purification: Crude peptide is purified by reverse-phase high-performance liquid chromatography (RP-HPLC) to remove synthesis byproducts, truncation sequences, and deletion analogs