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Triggered by ghrelin receptor activation Can lead to unintended fat gain if unmanaged Typically subsides slightly over time MK-677 significantly increased appetite due to its ghrelin-mimetic properties, making it a double-edged sword for body composition. Patel et al., The Journal of Clinical Endocrinology & Metabolism 2

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67), S47S53 (2011)

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Providers consider current health status, medication safety, digestive history, family and personal medical history, prior weight loss attempts, and treatment goals before recommending Tirzepatide