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Another example with different in vitro and in vivo performances involves melatonin, a hormone secreted by the pineal gland that plays an important role in sleepwake regulation

Methods: Lipodystrophic insulin resistant and glucose intolerant seipin knockout mice were treated with the GLP-1R agonist liraglutide either acutely preceding analyses of insulin and glucose tolerance or chronically prior to metabolic phenotyping and ex vivo studies

Molting in the mature female blue-crab, callinectes-sapidus rathbun

Nature Reviews Endocrinology, 19, 460476

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