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Treatment with galanin or apelin, which are both peptides released in the intestine, results in decreased duodenal contraction via the ENS, which subsequently signals to the hypothalamus, leading to increased hypothalamic NO release and whole-body glucose utilization 79,80

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"Regulatory Compliance and Quality Assurance in Pharmaceutical Intermediate Manufacturing." International Pharmaceutical Manufacturing Review, Vol

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In more recent times, lorcaserin (Belviq) was also withdrawn, due to an increased risk (albeit only 9%) of cancer [49] , which the FDA deemed as not being outweighed by the benefits of lorcaserin for any identifiable patient population