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However, it remains unapproved by the FDA and banned for human use in many countries due to the lack of human trials and concerns over safety, contamination, and legal misuse

Reported adverse effects in small human studies include headache, dizziness, and transient blood pressure changes

doi: 10.3389/fvets.2025.1502236 Received 26 September 2024 Accepted 21 May 2025 Published 30 June 2025 Volume 12 - 2025 Edited by Maurice Pitesky, University of California, Davis, United States Reviewed by Blagica Sekovska, Saints Cyril and Methodius University of Skopje, North Macedonia Christine Pye, University of Liverpool, United Kingdom Updates Copyright 2025 Tarrant, Rai, Wright, Street and Wells

Research Applications Published Research Peer-reviewed studies from PubMed

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Comprehensive transcriptomic analysis revealed relatively low expression levels in both the control and single-natural product groups