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Senescent mitochondria not only produce more ROS due to inefficient electron transport but also exhibit impaired iron-sulfur cluster biogenesis, leading to improper iron handling and accumulation within the mitochondria, thus creating a potent internal source of oxidative stress (106,107)

Originally, in response to GnRH secretion from hypothalamus, anterior pituitary gonadotrophs secrete the LH and FSH [25]

Combination of four clinical indicators predicts the severe/critical symptom of patients infected COVID-19