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[11] [12] Safety Considerations When Combining These Medications When taking Wegovy and bupropion together, several safety considerations should guide your treatment: Monitoring for Side Effects: Both medications have distinct side effect profiles that require attention: Wegovy : Nausea, vomiting, diarrhoea, constipation, abdominal pain, headache, fatigue, and injection site reactions

Clinical Pharmacokinetics, 60(10), 13351348