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Although brain infarction volume reduction did not reach statistical significance, motor performance in the rotarod test significantly recovered in DSIP-treated animals compared to vehicle controls confirming a functionally relevant neuroprotective effect at the behavioural level and establishing intranasal delivery as a viable route for CNS DSIP research

The two fusion proteins were designed with either an intact C-terminal end (GLP-1 WT and GLP-1 QMP) or a truncated end lacking L585 (GLP-1 LX and GLP-1 QMP/LX) (Fig