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Shaking introduces mechanical stress that can break the delicate peptide bonds, a process called shearing

Neurological Sciences 36 (11): 20892096

While vitamin B12 supplementation can offer significant benefits, its important to exercise caution and consult with a healthcare provider, especially if certain conditions are present

British Journal of Nursing 2014

If you suspect you have experienced side effects from a prescribed B12 medicine, you can report this through the MHRA Yellow Card scheme

[44] [41] Vitamin B 12 is not one of the supplements recommended by the World Health Organization for healthy women who are pregnant, [14] however, vitamin B 12 is often suggested during pregnancy in a multivitamin along with folic acid [45] [46] especially for pregnant mothers who follow a vegetarian or vegan diet