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Downregulation of GLP-1 and GIP receptor expression by hyperglycemia possible contribution to impaired incretin effects in diabetes

If you normally inject Friday and experience peak nausea on Sunday, and you have a big Sunday event, consider injecting Wednesday instead

( H ) Intracellular cAMP accumulation in human caSMCs treated with the sAC inhibitor KH7 (25 M, dark gray bars), the tmAC inhibitor Ddox (50 M, white bars), or PBS (light gray bars) for 3 hours followed by a 15-minute treatment with GLP-1(2836), scrambled control, IPE, or forskolin

Summary of included pre-clinical and mechanistic studies regarding the effects of GLP-1-RAs on mental health outcomes)

However, in vitro, evidence suggests that hyperglycemia, a primary metabolic feature of T2DM, can lead to impaired GLP-1 secretion and L-cell differentiation

doi: 10.1186/s13063-021-05442-y 161 ChenHLiuSGaoSShiHYanYXuYet al