In these participants, concentrations of latent myostatin, a pharmacodynamic marker, increased substantially after the first dose, achieved a plateau at approximately week 16 and remained consistently elevated throughout the treatment period, demonstrating successful target engagement (Extended Data Fig
The main consideration is gastrointestinal tolerance: both drugs can cause nausea, diarrhea, or abdominal discomfort, particularly in the first 24 weeks of semaglutide initiation
if confirmed, semaglutide should not be restarted
Dosing errors are unlikely to cause serious harm
doi:10.1210/jc.2004-1719 Berlanga-Acosta J, Abreu-Cruz A, Herrera DGB, et al
That confusion is common because semaglutide began as a diabetes drug before becoming widely known for weight management