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H HR-MAS NMR metabolomics has demonstrated that serine levels are significantly elevated in endometrial cancer tissues (G1, G2, G3) compared with normal endometrial tissues, and increase with tumor grade, showing a positive correlation with malignancy ( 4.1.4 Hepatocellular carcinoma PRMT1 binds to valine 83 (V83) of PHGDH and catalyzes the methylation of arginine 236 (R236) on PHGDH, thereby increasing the affinity of PHGDH for its substrate 3-phosphoglycerate and markedly enhancing enzymatic activity

Epub 2017 Apr 13

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Am J Hematol 94:E325E328

sFNDC5 and irisin can be produced upon GLP-1 treatment of pancreas, brain tissue, and possibly other organs and then circulated to adipose tissues

Table 2) has been undergoing clinical trials for the treatment of CKD with type 2 diabetes mellitus [15,16]