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Although rare, there is a concern that probiotics may cause infection

Westgate CS, Botfield HF, Alimajstorovic Z, et al

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The following changes may indicate that the product has degraded and should not be used: Cloudiness or haziness in the solution, which may suggest protein aggregation or contamination Visible particles or floaters suspended within the liquid Discolouration any shift towards brown, orange, or notably deeper yellow tones Crystalline deposits along the walls of the vial or cartridge, which may indicate freezing has occurred Leaking, cracked, or damaged packaging or devices, which compromise sterility It is worth noting that some changes in stability may not be visible to the naked eye, yet the product's potency may still have been compromised by improper storage

Not everyone will experience side effects and some patients may experience some while others experience completely different ones

Often the dramatic weight loss from calorie restriction is a result of loss of both fat and muscle