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Rotating injection sites between abdomen, thigh, and upper arm is a common practice to reduce local irritation

The formulations are injected using a 27 G or 30 G needle through the tympanic membrane into the superior posterior quadrant behind which the round window niche is located

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It is suggested that GS1 and GS2 may exert their effects by inhibiting TLR4/MyD88/TRIF/NLRP3 signaling pathway

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Reconstitution and administration for both peptides Both cagrilintide and retatrutide are typically supplied as lyophilized (freeze-dried) powders that require reconstitution with bacteriostatic water before use