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MIA, an inhibitor of glyceraldehyde-3-phosphate dehydrogenase, can disrupt chondrocyte glycolysis and ultimately lead to cell death, thereby contributing to cartilage degradation, subsequent alterations in subchondral bone, and the development of osteophytes 25,34

Glycodelin mediates the increase in vascular endothelial growth factor in response to oxidative stress in the endometrium

Consequently, start at a slow rate (1-2ml per minute) for the first 5 minutes to assess tolerance, then increase to the target rate

Blisters indicate the laser worked leave them intact

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