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It has a molecular weight of 268.3 g/mol and a molecular formula of C 16 H 12 O 4 (Fig

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Discussion Our structural and functional analyses reveal that binding of one IGF1 molecule to IGF1R disrupts the -shaped autoinhibited IGF1R dimer and triggers a conformational rearrangement that leads to the formation of an asymmetric -shaped active dimer (Fig

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