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Thus, the observed absence of metastasis in the triple therapy group may also reflect the important contribution of the HGF/c-MET inhibition component of the triple therapy, which significantly downregulates EMT of cancer cells

15%), with the latter being further subdivided into squamous cell carcinoma (SCC), large cell carcinoma (LCC), and adenocarcinoma [151,152,153,154]

At baseline (Week 26) for the two groups combined, mean age was 48 years

These beneficial effects were linked to enhanced formation of filamentous actin (F-actin) and activation of key cytoskeletal signaling pathways, including focal adhesion kinase (FAK) and paxillin

Many formulations also incorporate L-carnitine (to support fatty acid oxidation), B-complex vitamins , and MIC blends (methionine, inositol, choline)