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35 Without this stimulus, especially during a calorie deficit potentially exacerbated by GLP-1 effects, the body may be less efficient at utilizing dietary protein for muscle maintenance, leading to greater lean mass loss

However, most patients notice weight loss within the first two weeks of treatment

PMID: 40368220 Exp Neurol Lactiplantibacillus plantarum SG5 inhibits neuroinflammation in MPTP-induced PD mice through GLP-1/PGC-1 pathway

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But even as he calls for more robust data on long-term outcomes and safety in older adults, Batsis says that his skepticism regarding the benefits of these drugs has decreased over the past few years