Signs you should slow down the titration Extend your stay at the current dose by 2-4 additional weeks if you experience any of the following at the end of a standard 4-week period: Nausea persisting beyond the first 7 days after the last dose increase Vomiting more than twice per week Diarrhea lasting more than 10 days at the current dose Significant fatigue or weakness that does not improve with adequate nutrition and rest Weight loss exceeding 1.5% per week (too-rapid loss increases gallstone risk and muscle loss) Slowing the titration is not failure
During these appointments, your healthcare provider will assess your progress, review blood test results, and make any necessary adjustments to your treatment plan
We recommend you front load your hydration in the morning and taper off by dinnertime so that you are not getting up to use the bathroom more than once and disrupting your sleep
Licensed, NICE-recommended alternatives for weight management include semaglutide (Wegovy) and orlistat
Efficacy and safety of lixisenatide once-daily versus exenatide twice-daily in patients with type 2 diabetes insufficiently controlled on metformin (GetGoal-X) [abstract 786]
Tailored, doctor-led weight loss packages help ensure safety and sustainability.