Proteostasis and metabolic dysfunction characterize a subset of storage-induced senescent erythrocytes targeted for posttransfusion clearance
Notably, patients with mutations in GGT1 often present with developmental disorders, accumulation of GSH (glutathionaemia and glutathionuria) and reduced circulating levels of cystine 25
In light of these intricate phenomena, a therapeutic approach can be challenging
Quantification was performed using calibration curves and the identification was done with a custom database
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Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice